Chinese research: HIV drugs do not work in severe corona form



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Chinese research: HIV drugs do not work in severe corona form



A TABLET containing two HIV drugs, which has been cited as a possible cure for new coronavirus, is not effective, according to a study published Wednesday in the New England Journal of Medicine.

A study of Chinese patients with severe Covid-19 disease found that 99 patients who received Kaletra from AbbVie Inc, a combination of lopinavir and ritonavir, did not perform better than 100 patients on standard care.



People who received this medicine showed slight improvements over the 28 days in clinical recovery and mortality, but the differences were not statistically significant.

In patients on this combination of drugs, clinical improvement was shown after an average of 15 days compared to an average improvement after 16 days in those on standard inpatient therapy, a difference that scientists described as “significant but modest”.

The results are published online at the New England Journal of Medicine website.

The lopinavir-ritonavir combination caused more side effects and in 13.8 percent of patients this treatment was discontinued.

The study did not use a placebo group, which is the gold standard in assessing the effectiveness of a treatment.

All patients had pneumonia and were treated at Jin Yin-Tan Hospital in Wuhan, the city where the pandemic erupted.

Treatment with a combination of HIV drugs “was not associated with clinical improvements or mortality in Covid-19 patients different from standard care alone,” concluded the team led by Dr. Bin Caoom from the National Center for Clinical Trials for Respiratory Diseases.

The test was a “heroic endeavor,” they said. Lindsey Baden et al. Eric J. Rubin, editors of the New England Journal of Medicine in the editorial. “Unfortunately, the test results are disappointing.”

The treatment had “no apparent effect” on the multiplication of the virus, which is how the therapy should work, they concluded.

The combination of HIV, a human immunodeficiency virus that causes AIDS, has been used in many countries in the hope of being effective.

Chinese research: HIV drugs do not work in severe corona form

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